Synthesis and In-vitro Biological Analyses of New quinazolin-2,4-dione Derivatives

Document Type : Original Article

Authors

1 National research centre

2 Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt

3 Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute

4 5Department of Toxic and Narcotic drug, Forensic Medicine, Mansoura Laboratory, Medicolegal organization, Ministry of Justice, Egypt

5 3Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt.

Abstract

A series of quinazolin-2,4-dione analogues (1-17a,b) were prepared and their chemical structures were confirmed using spectral and microanalytical data. Analysis of the in vitro cytotoxic effect of the synthesized compounds using RBCs toxicity assay was achieved. Also, biological screening on their potential anticancer effect on hepatocellular carcinoma cell line (HepG2) and their antimicrobial activity against three microbes (bacteria, yeast, and fungus) was studied. Only two compounds 5 and 17b had a moderate anti-HCC activity with calculated IC50 equals 382.9±6.9 µg/ml and 415.8±3.8 µg/ml, respectively. Compound 9 had the highest anti-Aspergillus niger effect, compound 5 had the highest anti-Candida albicans effect, compound 6 had the highest anti-Staphylococcus aureus effect, and compound

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  • Receive Date: 18 December 2021
  • Revise Date: 14 January 2022
  • Accept Date: 23 January 2022
  • First Publish Date: 23 January 2022