TY - JOUR ID - 215446 TI - Synthesis and In-vitro Biological Analyses of New quinazolin-2,4-dione Derivatives JO - Egyptian Journal of Chemistry JA - EJCHEM LA - en SN - 0449-2285 AU - Rashdan, H.R.M. AU - Okasha, H. AU - Abdelhakeem, M. A. AU - Mosallam, A. M. AU - Temairk, H. AU - Alhamzani, A.G. AU - Abou-Krisha, M.M. AU - yousef, T.A. AU - Abdelmonsef, A.H. AD - Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Institute, Dokki, Cairo 12622, Egypt. AD - Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt. AD - Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt. AD - Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia. Y1 - 2022 PY - 2022 VL - 65 IS - 9 SP - 189 EP - 199 KW - Quinazolin-2 KW - 4-diones KW - HCC KW - RBCs toxicity KW - antimicrobia DO - 10.21608/ejchem.2022.111820.5077 N2 - A series of quinazolin-2,4-dione analogues (1-17a,b) were prepared and their chemical structures were confirmed using spectral and microanalytical data. Analysis of the in vitro cytotoxic effect of the synthesized compounds using RBCs toxicity assay was achieved. Also, biological screening on their potential anticancer effect on hepatocellular carcinoma cell line (HepG2) and their antimicrobial activity against three microbes (bacteria, yeast, and fungus) was studied. Only two compounds 5 and 17b had a moderate anti-HCC activity with calculated IC50 equals 382.9±6.9 µg/ml and 415.8±3.8 µg/ml, respectively. Compound 9 had the highest anti-Aspergillus niger effect, compound 5 had the highest anti-Candida albicans effect, compound 6 had the highest anti-Staphylococcus aureus effect, and compound UR - https://ejchem.journals.ekb.eg/article_215446.html L1 - https://ejchem.journals.ekb.eg/article_215446_886571ee14090c540b7fa5409eea7e25.pdf ER -