%0 Journal Article %T Synthesis and In-vitro Biological Analyses of New quinazolin-2,4-dione Derivatives %J Egyptian Journal of Chemistry %I National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT %Z 0449-2285 %A Rashdan, H.R.M. %A Okasha, H. %A Abdelhakeem, M. A. %A Mosallam, A. M. %A Temairk, H. %A Alhamzani, A.G. %A Abou-Krisha, M.M. %A yousef, T.A. %A Abdelmonsef, A.H. %D 2022 %\ 09/01/2022 %V 65 %N 9 %P 189-199 %! Synthesis and In-vitro Biological Analyses of New quinazolin-2,4-dione Derivatives %K Quinazolin-2 %K 4-diones %K HCC %K RBCs toxicity %K antimicrobia %R 10.21608/ejchem.2022.111820.5077 %X A series of quinazolin-2,4-dione analogues (1-17a,b) were prepared and their chemical structures were confirmed using spectral and microanalytical data. Analysis of the in vitro cytotoxic effect of the synthesized compounds using RBCs toxicity assay was achieved. Also, biological screening on their potential anticancer effect on hepatocellular carcinoma cell line (HepG2) and their antimicrobial activity against three microbes (bacteria, yeast, and fungus) was studied. Only two compounds 5 and 17b had a moderate anti-HCC activity with calculated IC50 equals 382.9±6.9 µg/ml and 415.8±3.8 µg/ml, respectively. Compound 9 had the highest anti-Aspergillus niger effect, compound 5 had the highest anti-Candida albicans effect, compound 6 had the highest anti-Staphylococcus aureus effect, and compound %U https://ejchem.journals.ekb.eg/article_215446_886571ee14090c540b7fa5409eea7e25.pdf