Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

Ghoneim, Amira A.; Elbargisy, Rehab M.; Manoer, Afaf

doi:10.21608/ejchem.2020.21641.2289

Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

Document Type : Original Article

Authors

¹ Chemistry Department, College of Science, Jouf University, P. O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia. Tel.: 00966541609390.

² Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

³ Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, AlJouf, Saudi Arabia

⁴ Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

⁵ Chemistry Department, College of Science, Jouf University, P. O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia. Tel.: 00966541609390

10.21608/ejchem.2020.21641.2289

Abstract

In this present work, synthesized a novel derivatives of bis-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds 4a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, 1HNMR, 13CNMR, and elemental analysis. The new compounds have been screened as anti-bacterial activity

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