Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines

Bollikolla, HARI BABU; G, Ravi Kumar; B, S N Murthy; M, Santha Kumari

doi:10.21608/ejchem.2019.16652.2014

Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines

Document Type : Original Article

Authors

¹ DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA

² Department of Chemistry, Government Degree College, Husnabad-505467, Telangana, India.

³ Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India

⁴ Department of Chemistry, Government Degree College for Women (A), Srikakulam-532001, Andhra Pradesh, India

10.21608/ejchem.2019.16652.2014

Abstract

A series of 16 new (±) -1-(4-(3-fluorobenzyloxy) pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives were synthesized from 2,5-dihydro-1H-pyrrole. Sixteen compounds are well characterized by their 1H NMR, 13C NMR and mass spectral data. Anticancer activities of these compounds were tested against HCT 116, MDA-MB231, Mia-PaCa2 cancer cell lines. Among these series of compounds, 8b exhibited highest activity with IC50 of 42.5 µg/ mL against MDA-MB231 cell line. The compound 8o and 8n showed moderate activity with IC50 of 64.3 µg/ mL and 68.4 µg/ mL against HCT -116 and Mia-PaCa2 cancer cell lines respectively.

Keywords