Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

Al-Wasidi, Asma S.; Naglah, Ahmed M.; Refat, Moamen; El-Megharbel, Samy M.; Kalmouch, Atef; Moustafa, Gaber Osman Mohamed

doi:10.21608/ejchem.2020.21193.2263

Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia

² Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622- Dokki, Cairo, Egypt

³ Taif University

⁴ El-Tahreer str 456

10.21608/ejchem.2020.21193.2263

Abstract

Synthesis and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated –NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.

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