Human health and nutrition are profoundly influenced by the combined effects of prebiotics and probiotics, which play essential roles in promoting digestive health and preventing disease. Prebiotics are non-digestible compounds that selectively stimulate the growth of beneficial gut bacteria, serving as a fuel source for probiotics. Probiotics, live microorganisms that confer health benefits, have demonstrated therapeutic potential in managing conditions such as irritable bowel syndrome, inflammatory bowel disease, and infections in the gut, respiratory system, and urogenital tract. Additionally, probiotics and the gut microbiota influence drug metabolism, affecting drug activation, toxicity, and efficacy. Examples include the sulfation of acetaminophen, dehydroxylation of caffeine, and glucuronidation, a process that enhances drug solubility and reduces toxicity. These interactions underscore the microbiota’s role in modulating metabolic and therapeutic processes. Despite their recognized benefits, systematic reviews on the types, mechanisms, and relationship of prebiotics and probiotics remain limited. This review provides a comprehensive analysis of their classifications, functional pathways, and synergistic effects in promoting gut health and optimizing metabolic processes. We offer insights into innovative applications and propose directions for future research to maximize their potential in health management.
Alsufyani, M. O., Asiri, A. A., Asiri, Y. M., Alsughayyir, I. A., Alzahrani, R. A., Al Essa, T. A., Lajhar, A. M., Alshhrani, M. A., & Rabeh, M. A. (2024). Correlation between Probiotic and Prebiotic: A Systematic review. Egyptian Journal of Chemistry, 67(13), 2227-2244. doi: 10.21608/ejchem.2025.327475.10617
MLA
Mohammed O. Alsufyani; Alhussain A. Asiri; Younis M. Asiri; Ibrahim A. Alsughayyir; Rayan A. Alzahrani; Thamer A. Al Essa; Ahmed M. Lajhar; Mesfer A. Alshhrani; Mohamed A. Rabeh. "Correlation between Probiotic and Prebiotic: A Systematic review", Egyptian Journal of Chemistry, 67, 13, 2024, 2227-2244. doi: 10.21608/ejchem.2025.327475.10617
HARVARD
Alsufyani, M. O., Asiri, A. A., Asiri, Y. M., Alsughayyir, I. A., Alzahrani, R. A., Al Essa, T. A., Lajhar, A. M., Alshhrani, M. A., Rabeh, M. A. (2024). 'Correlation between Probiotic and Prebiotic: A Systematic review', Egyptian Journal of Chemistry, 67(13), pp. 2227-2244. doi: 10.21608/ejchem.2025.327475.10617
VANCOUVER
Alsufyani, M. O., Asiri, A. A., Asiri, Y. M., Alsughayyir, I. A., Alzahrani, R. A., Al Essa, T. A., Lajhar, A. M., Alshhrani, M. A., Rabeh, M. A. Correlation between Probiotic and Prebiotic: A Systematic review. Egyptian Journal of Chemistry, 2024; 67(13): 2227-2244. doi: 10.21608/ejchem.2025.327475.10617
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