Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions

Document Type : Review Articles

Authors

King Saud Medical City, Riyadh, Saudi Arabia

Abstract

Background: Platelet hyperactivity has a central role in the process of thrombosis during important stages like injury, sepsis, and cardiovascular events. Platelets are required for hemostatic plug formation, but the activation of platelets can also result in formation of pathological thrombi and life threatening events.
Aim: The goal of the present research is to examine the metabolic background of platelet hyperactivity and its implication in thrombosis in severe medical conditions.
Methods: A literature review was performed and the findings based on the biochemical processes accounting for platelet activation and aggregation during trauma, sepsis and cardiovascular diseases have been reported.
Results: The review identified that inflammation, oxidative stress and endothelial dysfunction are main factors that influence the platelet activation and thereby enhancing the thrombus formation and corresponding risks of stroke, myocardial infarction and pulmonary embolism.
Conclusion: Hyperactivity of platelets is essential during thrombosis in critical conditions. Knowledge of such biochemical pathways displays practical approaches on how the thrombotic risks that are so characteristic of individual critically endangered can be controlled.

Keywords

Main Subjects

Egyptian Journal of Chemistry
Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 1787-1793

Files

History

  • Receive Date: 18 December 2024
  • Revise Date: 28 December 2024
  • Accept Date: 31 December 2024

Share

How to cite

Statistics