ANTIBIOTIC OXYTETRACYCLINE SOLVATION INTERِِCTIONS WITH ETHANOL-AQUEOUS MIXTURS AT DIFFERENT TEMPERATURES

Abouelleef, Elsayed; Helmy, Elsayed T

doi:10.21608/ejchem.2019.8105.1634

ANTIBIOTIC OXYTETRACYCLINE SOLVATION INTERِِCTIONS WITH ETHANOL-AQUEOUS MIXTURS AT DIFFERENT TEMPERATURES

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Arts and Science, Rafha, Northern Border University, 91911 Rafha, Kingdom of Saudi Arabia.

² Marine Pollution Research Lab., National Institute of Oceanography and Fisheries, Ministry of Scientific Research, Alexandria, Egypt.

10.21608/ejchem.2019.8105.1634

Abstract

Abstract: The solubility is one of the vital parameters to attain the specified concentration of the drug in circulation for the desired (anticipated) pharmacologic response. This work aimed to calculate ion-solvent interaction, the density of ethanol-water (EtOH-H2O) mixtures; the density of oxytetracycline (OTC) saturated solutions, different volumes of solvation (Van der Waals volume, molar volume and electrostriction volume and solvated radii (ro)) from solubility data. It was found that; the activity coefficient (γ_±) of OTC were decreased by increasing the EtOH content in (EtOH-H2O) mixture used and also the logγ_± decrease within the rise in temperature. The densities and also the molar volume of OTC decrease by increasing the quantitative ratio of EtOH and also was increased by rising in temperature. The electrostriction volumes and therefore the solvated radii (ro) of OTC are increased as the EtOH content increase and also are increased by the rise in temperature.

Keywords