1,2,3-Triazole-Based Chitosan Derivatives: Recent Aspects, Synthesis and Therapeutic Potential

Document Type : Review Articles

Authors

1 Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

2 Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Abstract

The integration of 1,2,3-triazole derivatives into medicinal chemistry has emerged as a promising strategy for enhancing the efficacy of therapeutic agents. These compounds demonstrate a broad spectrum of biological effects, such as antifungal, antimicrobial, anti-inflammatory, and anticancer activities.Chitosan, a biocompatible and biodegradable polymer derived from chitin, provides an excellent matrix for the development of functionalized materials. The incorporation of triazole moieties into chitosan and its derivatives through click chemistry enhances their therapeutic potential and expands their applications in biomedical fields. These chitosan-based materials can be engineered for drug delivery systems, improving the solubility and stability of therapeutic agents, as well as for wound healing applications, due to their inherent antimicrobial properties.This review highlights the recent advancements in the application of triazole derivatives in medicinal chemistry and the innovative use of click chemistry in developing chitosan and chitosan derivative-based materials. The synergy between triazole chemistry and chitosan functionality presents exciting opportunities for the design of novel therapeutics and delivery systems, addressing key challenges in contemporary pharmaceutical research

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Egyptian Journal of Chemistry
Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 1317-1331

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History

  • Receive Date: 08 November 2024
  • Revise Date: 27 November 2024
  • Accept Date: 03 December 2024

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