Younis, A., Awad, G. (2020). Utilization of Ultrasonic as an Approach of Green Chemistry for Synthesis of Hydrazones and Bishydrazones as Potential Antimicrobial Agents. Egyptian Journal of Chemistry, 63(2), 599-610. doi: 10.21608/ejchem.2019.13440.1833
Ahmed Younis; Ghada Awad. "Utilization of Ultrasonic as an Approach of Green Chemistry for Synthesis of Hydrazones and Bishydrazones as Potential Antimicrobial Agents". Egyptian Journal of Chemistry, 63, 2, 2020, 599-610. doi: 10.21608/ejchem.2019.13440.1833
Younis, A., Awad, G. (2020). 'Utilization of Ultrasonic as an Approach of Green Chemistry for Synthesis of Hydrazones and Bishydrazones as Potential Antimicrobial Agents', Egyptian Journal of Chemistry, 63(2), pp. 599-610. doi: 10.21608/ejchem.2019.13440.1833
Younis, A., Awad, G. Utilization of Ultrasonic as an Approach of Green Chemistry for Synthesis of Hydrazones and Bishydrazones as Potential Antimicrobial Agents. Egyptian Journal of Chemistry, 2020; 63(2): 599-610. doi: 10.21608/ejchem.2019.13440.1833
Utilization of Ultrasonic as an Approach of Green Chemistry for Synthesis of Hydrazones and Bishydrazones as Potential Antimicrobial Agents
2Pharmaceutical and Drug Industries Research division
Receive Date: 03 June 2019,
Revise Date: 29 June 2019,
Accept Date: 02 July 2019
Abstract
Hydrazides 3,4, Hydrazones 6a-c, bishydrazones 8a,b, N-hydroxy-N'-arylpropanehydrazonamide 9a,b and 1-(piperidin-1-yl)-N2-arylamidrazones 10a,b were prepared under ultrasonic waves as an approach for green chemistry. a notable good yield and short reaction time were afforded under ultrasonic waves.The structures of compounds were confirmed in terms of spectroscopic and elemental analyses. The invitro antimicrobial activity of the prepared compounds were evaluated. most of compounds exhibited an excellent growth inhibition such as compounds 2, 3 and 8b against gram positive bacteria, while 2, 3, 8b, 9a, 10a and 10b against gram negative bacteria. all of tested compounds have excellent or good antifungal activity except 3
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