Utilization of Acrylic Modified PET and Its Nanocomposite Fibers in Transdermal Medical Applications

Document Type : Original Article

Authors

1 National Research Center

2 National research centre

3 National Research Centre, polymers and pigments department

Abstract

Polyethylene terephthalate /Montmorillonite clay nanocomposite was prepared using commercially modification Montmorillonite (MMT). The prepared nanocomposite was characterized using scanning electron microscope (SEM). Fibers of pure Polyethylene terephthalate (PET) and Polyethylene terephthalate /montmorillonite clay nanocomposite (PET/MMT) were produced using melt spinning technique. Grafting of Acrylic acid was performed using grafting emulsion polymerization technique to obtain PET/MMT-g-AA fibre and the prepared fibers were characterized using mechanical properties, FTIR in addition to SEM analysis. The results show that the PET/MMT-g-AA fibre have higher mechanical properties, and lower water absorption than pure PET and PET/MMT fibers in addition to high degree in homogeneity between PET and MMT clay in PET/MMT fibre. Clindamycin drug was successfully loaded into PET, PET/MMT and PET/MMT-g-AA fiber via solvent immersion method with different drug fiber ratio in presence of glyoxal crosses linker. Drug release profile was studied for 120 min and the results showed that about 41% from the initial loaded drug was released from the fiber after an hour of release starting time.

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Egyptian Journal of Chemistry
Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 379-385

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History

  • Receive Date: 23 December 2023
  • Revise Date: 19 January 2024
  • Accept Date: 05 February 2024

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