Neuroprotective Effect of Cardamom Essential Oil Encapsulated Nanoparticles and Swimming in Aluminum Induced Alzheimer’s disease in Rats

Document Type : Original Article


1 Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

2 Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

3 Department of pharmacology, National Research Centre, Cairo, Egypt

4 Department of Chemistry of Flavour and Aroma, National Research Centre, Cairo, Egypt.

5 Food Technology Dep., National Research Centre, Dokki, Egypt

6 Department of Pathology, National Research Centre, Cairo, Egypt.


As there is currently no cure for Alzheimer's disease (AD), considerable research is required to create plans to block the processes that cause memory loss. Functionalized nanomedicines that are nanoparticles contain central core structures that guarantee the encapsulation to offer protection and longer blood circulation. The purpose of this study was to investigate the neuroprotective effects of swimming exercise and nanoparticle-encapsulated cardamom oil (NCEO) on aluminum chloride-induced oxidative damage in experimental rats used as models for Alzheimer's disease. Experimental rats were induced for AD then groups were divided into different treatment groups; dopenzil, NCEO and swimming training. Different biochemical and pathological parameters were evaluated in both serum and muscles. Results showed and improvement in the concerned parameters with different treatment strategies. It can be concluded that both swimming and NCEO can be advised for AD patients.


Main Subjects

Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 37-52
  • Receive Date: 18 December 2023
  • Revise Date: 23 January 2024
  • Accept Date: 31 January 2024