Facile One-Pot Strategy For Radiopreprationof Radioiodinated Phenylpiracetam As A New Highly Selective Radiotracer For Brainimaging

Document Type : Original Article

Authors

1 Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt

3 Food Toxicology and Contaminants Department, National Research Centre, Dokki 12622, Cairo, Egypt

Abstract

The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizing agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.

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Egyptian Journal of Chemistry
Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 189-198

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History

  • Receive Date: 22 December 2023
  • Revise Date: 15 January 2024
  • Accept Date: 24 January 2024

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