Egyptian “Ful Medames” Mitigates Metabolic Syndrome-Associated Inflammation through Regulation of Resistin, Leptin and Adipokine mRNA Expression in Wistar Rats

Document Type : Original Article


1 Nutrition & Food Science Dept., Institute of Food Industries & Nutrition Research, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt.

2 Environmental and Occupational Medicine department, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt.

3 Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

4 Food Technology Department, Institute of Food Industries & Nutrition Research, National Research Centre, Dokki, Cairo, P.O. 12622, Egypt.


Metabolic syndrome is among the serious global health problems and is usually associated with inflammation. Dietary aspects contribution and genetic associations to minimize metabolic syndrome disorders and inflammation is a controversy point. The present study aims to evaluate the ability of the most popular Egyptian meals “Ful-Medames” to mitigate the metabolic syndrome associated disorders and inflammation in Wistar rats and its impact on the expression regulation of the white adipose tissue mediators; resistin, leptin and adiponectin. Three groups of male albino rats were used; negative, positive with induced metabolic syndrome and Ful-Medames fed group pre-induced for metabolic syndrome lasting for four weeks. Results revealed a high protein content of 26.56% for Ful-Medames, considerable antioxidant activity and polyphenolic compounds as detected by HPLC. Biochemical findings revealed restoring of the changed levels of blood glucose, total cholesterol, triglycerides, HDL-C, LDL-C, transaminases’ activity, insulin resistance, CRP and hepatosomatic index with marked improvement of changes in histopathological and resistin, leptin and adiponectin expression for the Ful-Medames fed metabolic syndrome group. Thus, it can be concluded that “Ful-Medames” counteracts metabolic syndrome-associated disorders and inflammation through restoring the disordered expression regulation of resistin, leptin and adiponectin.


Main Subjects

Volume 67, Issue 13 - Serial Number 13
In Loving Memory of Late Professor Doctor ””Mohamed Refaat Hussein Mahran””
December 2024
Pages 403-420
  • Receive Date: 24 December 2023
  • Revise Date: 18 January 2024
  • Accept Date: 23 January 2024