Macromolecules cross linked-metal organic frame works based sensors for determination of memantine hydrochloride

Document Type : Original Article

Authors

1 Microanalysis Laboratory, Applied Organic Chemistry Department, Industries Research Division National Research Centre, El Bohouth st., Dokki, 12622-Giza, Egypt

2 Faculty of Science, Al-Azhar University

3 Chemistry Department, Faculty of Science, Al-Azhar University

4 Faculty of Science (Girls), Al Azhar University, Naser City, Egypt

5 a) Microanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre, El Bohouth St., Dokki, 12622 Giza, EgyptAnal Chem. Lab, NRC

Abstract

Fabrication of electrochemical sensors by screen printing technology represents a promising approach for fabrication of a planner electrochemical sensor. Herein, a novel memantine hydrochloride (MEM) potentiometric disposable sensor was constructed based on β-cyclodextrin-metal organic framework-multiwall carbon nanotube composite (β-CD-MOF-MWCNTs) as a selective recognition element for memantine molecule. Improved sensitivity was recorded within the MEM concentration ranged from 10-6 to 10-2 molL-1 with a theoretical Nernstian compliance value 60.5±0.9 mV decade -1 and a limit of detection value of 7.0×10 -7 molL-1. The fabricated disposable sensors showed long shelf lifetime (24 weeks) and fast response time (3s) which may be attributed to the incorporation of covalently bonded ionophore nanocomposite within the electrode matrix. The modified sensors were applied for determination of MEM in biological and pharmaceutical samples with high precision and accuracy. The developed sensors integrated with β-CD-MOF-MWCNTs offer approach for monitoring of the dissolution and degradation studies of memantine.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 2059-2071

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History

  • Receive Date: 09 September 2023
  • Revise Date: 01 October 2023
  • Accept Date: 10 October 2023

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