Gero-protective Impact of Astaxanthin on Experimental Model of Brain Aging: Biochemical and Molecular Study

Document Type : Original Article


1 Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia

2 Department of Chemistry , College of Science ,Umm Al Qura University, Makkah Al-Mukarramah, Saudi Arabia

3 Narcotics, Ergogenics, and Poisons Department , National Research Centre (NRC), Cairo, Egypt

4 Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education Ain Shams University , Cairo, Egypt.


Brain activity and multiple organ functions declined with aging. Although the complexity of brain aging process, releasing free radicals and inflammation were strongly linked to the disorder. Astaxanthin is a dietary carotenoid which exerts antioxidant and anti-inflammatory activities. We intended to estimate the protecting impact of Astaxanthin on aging caused by D-galactose. Forty male Wister rats were separated into 4 groups as follow: G1: (control) group:G2: (D-Gal) rats received D-Gal (300mg/kg,ip) ;G3 (D-Gal+Met) 4 h after D-Gal administration, rats received metformin (300 mg/kg, orally) , as reference drug group;G4 : (D-Gal+Asta) group: 4h after D-Gal treatment, rats received Astaxanthin (25 mg/kg , orally). Results showed that administering D-Gal caused brain aging manifested by significant (p<0.05) disturbance of antioxidant defense system, inflammatory biomarkers. Moreover, results of gene expression and histological assessment ensured biochemical findings. Astaxanthin supplementation promoted a remarkable significant (p<0.05) normalization in all parameters by triggering different brain mechanisms. In conclusion these results suggested that Astaxanthin modulates D-Gal induced brain-abnormalities associated with aging.