Pushing the Boundaries of Diversity: Innovative Design and Synthesis of Hydrazone-Based Dynamic Combinatorial Libraries of Macrocycles

Document Type : Original Article

Author

Department of Chemistry, College of Science and Arts, Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia

Abstract

Dynamic combinatorial chemistry (DCC) has emerged as a versatile approach for generating and discovering materials with diverse applications. Utilizing acylhydrazone formation, we developed new dynamic combinatorial libraries (DCLs) of macrocycles and open-structured compounds with intriguing diversity. The DCL constituents were generated via condensation reactions using functionalized dihydrazides and aldehydes. Time-of-flight mass spectrometry (TOF-MS) was employed to analyze the library constituents, showcasing its great potential for characterizing DCLs generated by DCC. Our findings highlight the effectiveness of TOF-MS in verifying and validating complex macrocycles generated in solution, making it a valuable technique for discovering new materials through identification and validation of DCLs.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 1555-1561

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History

  • Receive Date: 08 August 2023
  • Revise Date: 27 August 2023
  • Accept Date: 14 September 2023

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