Ameliorative Effects of Dietary Intake of Egg Yolk and Cod Liver Oil on Dexamethasone Induced Osteoporosis in Rats

Document Type : Original Article

Author

Nutrition & Food Science (PHD), Department pf Physical Sport Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

Abstract

This study examined how egg yolk and cod liver oil affected osteoporosis in rats induced by dexamethasone. Nutritional analysis showed that intake of egg yolk or cod liver oil increased body weight gain and feed efficiency ratio values. Biochemical analysis showed that bone mass loss was evident in the control +ve group, as evidenced by heightened levels of serum ALP, osteocalcin concentration (OC), urinary Ca, creatinine, uric acid, urinary nitrogen, as well as urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr). Bone mineral density and concentration (BMD&BMC), Ca, and P levels were decreased in the femur bone, indicating dexamethasone-induced osteoporosis. The intake of egg yolk or cod liver oil could maintain the levels of serum Ca, P, and OC. The intake of cod liver oil in osteoporotic rats increased excretion of Ca and Pyr, decreased urinary P, and showed no significant excretion of D-Pyr. The intake of egg yolk plus cod liver oil showed no significant changes in liver and renal function, except for elevated creatinine levels, and helped maintain normal levels of bone loss. Daily oral administration of egg yolk or cod liver oil, or both, for sixty days lowered the incidence of side effects of dexamethasone-induced osteoporosis.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 1741-1748

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History

  • Receive Date: 05 July 2023
  • Revise Date: 03 August 2023
  • Accept Date: 14 August 2023

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