Potential role of serum Neutrophil gelatinase-associated lipocalin and legume-based dietary therapy in alleviation of obesity-associated metabolic and renal disorders.

Document Type : Original Article


1 Department of Nutrition and Food Science, National Research Center, Cairo, Egypt

2 Nutrition and Food Sciences, National Research Centre, Egypt

3 Food Technology Dept., National Research Centre, El-Buhouth St., Dokki, Cairo, Egypt


Background: Lipocalin-2 (LCN-2) or Neutrophil Gelatinase Associated Lipocan (NGAL) is a biomarker for acute, chronic renal damage, and metabolic diseases. Aim: to evaluate the relation of serum NGAL with glycolipid metabolism and the inflammatory status among a sample of obese Egyptian women, and to study it as a sensitive biomarker to predict early changes in renal functions. Assess the role of specific dietary therapy in improving such conditions. Methods. The clinical trial study ran for 8 weeks and was divided into 2 sessions, 57 obese women with varying degrees of obesity and associated comorbidities took part as volunteers, their mean age and BMI were 50.84±1.48, 34.99±0.64 kg/m2. Patients were monitored clinically, anthropometrically, dietary 24 h recall for three successive and biochemically. In the first session all, participants followed a low caloric balanced regimen with a specific nutritional supplement that was omitted in the second phase. Results: All of the recorded anthropometric values improved after the intervention. Significant reductions in the mean concentrations of sNGAL, tumor necrosis factor-alpha (TNFα), and the other biochemical parameters were found in the first session, increasing after the omission of the supplement.. Data revealed constant significant correlations between sNGAL and age, FBG and TNFα along the study and with BMI, %BF, non-HDL-C and SBP at the different sessions. Conclusion: Data indicate that including chickpea in dietary therapy plus sNGAL up-regulation are involved in counteract obesity, glycolipid metabolism, chronic inflammation and the associated kidney disease.


Main Subjects

Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 1609-1619
  • Receive Date: 04 February 2023
  • Revise Date: 01 August 2023
  • Accept Date: 13 August 2023