New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Al-Azhar University at assiut

2 Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, Egypt

3 Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut

Abstract

Use pyrazolo[1,5-a]pyrimidine 4 as a precursor for synthesis of new heterocyclic compounds, where condensation with aromatic aldehydes gives arylidene derivatives 8a-c. Furthermore, when compound 4 is combined with aromatic diazonium chlorides 9a-c, it forms pyrazolo[3,4-d] pyridazines 11a-c. Additionally, reacting The unisolated potassium salt 13 with phenacyl bromide derivatives 14a,b or chloroacetonitrile at room temperature, thieno[3'',4'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidines 17a,b or 22 are obtained. Finally, compound 4 reacts with DMFDMA to produce enamine 23. The zone of inhibition measurement was used to gauge the synthetic compounds' in vitro antibacterial activity. The outcomes showed encouraging antibacterial efficacy against the harmful bacterial strains that were examined.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 2269-2278

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History

  • Receive Date: 25 April 2023
  • Revise Date: 14 June 2023
  • Accept Date: 18 June 2023

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