Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity

Document Type : Original Article

Authors

1 Microbial Biotechnology Department, National Research Centre, National Research Centre, 33 El-Buhouth Street, P.O. Box 12622, Dokki, Giza, Egypt

2 National research center, Cairo Microbial Chemistry department, National Research Centre, 33 El-Buhouth Street,

3 Botany and Microbiology Department, Faculty of Science, Benha Univ., Benha, Egypt.

4 Botany and Microbiology Dept., Faculty of Science, Banha University, Egypt.

Abstract

The finding as well as the subsequent medical history of antimicrobials has become one of the most significant game modifications in medical history. As a result, a natural substance of 2-Methyl butyl propyl phthalate was extracted from a marine-derived Streptomyces parvulus strain MDA remoted originating along the Red Sea coast; Hurghada. The elimination of Streptomyces parvulus strain MDA via 2-Methyl butyl propyl phthalate became an exciting topic in our study; locating was tested using a minimal bactericidal concentration (MBC) of 300 µg/ml and an 80 µg/ml minimum inhibitory concentration (MIC). The kinetic time killer graph illustrated that the microorganisms damaged cells in 5 hours. The fractionation and purification of 2-Methyl butyl propyl phthalate were completed by the use of silica gel column G254, thin layer chromatography (TLC), liquid chromatography (LC), and nuclear magnetic resonance (NMR), which helped in the elucidation of the structure of 2-Methyl butyl propyl phthalate with the molecular components of C16H22O4.

Keywords

Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 2331-2341

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History

  • Receive Date: 13 April 2023
  • Revise Date: 04 June 2023
  • Accept Date: 11 June 2023

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