Design, Structural Characterization, Molecular docking and Biomedical Applications Of Hydrazone-based Schiff base Metal Complexes

Document Type : Original Article

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Department of Chemistry, Faculty of Science, Cairo University, Egypt

Abstract

In this study, six mononuclear metal chelated complexes were designed and synthesized from a newly synthesized (E)-N′-((E)-1-(2-(p-tolyl)hydrazono)propan-2-ylidene)benzohydrazide Schiff base ligand. The chemical structures of the synthesized compounds were fully characterized using various techniques such as CHN analysis, infrared, proton nuclear magnetic resonance, mass spectral analysis, and conductivity measurements. The antioxidant activity of the metal complexes against active free radicals was determined through a 2,2-diphenyl-2-picryl-hydrazyl free radical scavenging experiment. Furthermore, all compounds were screened for antimicrobial, antifungal, and anticancer activities. Preliminary in vitro antibacterial and antifungal screening activities revealed that the complexes showed higher activity against the tested strains than those of the free ligand. The Mn(II) complex showed promising activity against HepG2 cells with very low IC50 (1.537 µg/ml). Molecular docking was used to predict the binding between the Schiff base ligand (L) and the different receptors. The docking study provided useful structural information for inhibition studies.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 1219-1230

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History

  • Receive Date: 31 July 2022
  • Revise Date: 13 April 2023
  • Accept Date: 25 May 2023

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