A Review on High Fat Diet-Induced Obesity and Natural Compounds' Role in the Management of Obesity

Document Type : Review Articles


1 Department of Biochemistry, Faculty of Science, University of Tabuk, 71491, Saudi Arabia

2 Biochemistry Division, Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt


Obesity is a global problem that causes severe health problems. Since, it increases the risk of developing chronic diseases, such as cardiovascular diseases, cancer, and type 2 diabetes. Pharmacotherapy is still the mainstay for managing obesity, but its efficacy is inadequate, it is non-specific, and it has harmful side effects, so its usefulness is limited. Therefore, it is essential to create new anti-obesity therapy methods or enhance currently available medications, in addition, novel ways could offer insights into obesity and obesity-associated disorders. Natural products, particularly plant extracts, are viewed as an alternative because they have no negative side effects. Plant extracts, in particular, contain antioxidant, anti-inflammatory, and insulin-sensitizing characteristics. Moreover, nanotechnology is one of the promising methods for increasing therapeutic efficacy and improving the anti-obesity effectiveness of these natural chemicals due to their alleged ability to be target-specific. Nanotechnology makes natural chemicals more bioavailable, biodistributable, stable, and soluble. This makes it a promising way to treat obesity.


Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 763-774
  • Receive Date: 04 January 2023
  • Revise Date: 01 May 2023
  • Accept Date: 13 May 2023