Facile synthesis of functional heterocycles utilizing activated Benzylideneacetones

Document Type : Original Article


1 Green Chemistry department, National research centre

2 Green chemistry Department, chemical industries Division, National Research Centre, 33 El Bohouth St. (former El-Tahrir St.), Dokki, Giza P.O. 12622, Cairo, Egypt

3 Basic Sciences Department, Modern Academy for Engineering &Technology, Cairo, Egypt,

4 Green chemistry department, National Research Centre


The utility of cinnamoylacetonitrile and chloroacetylcinnamates, as activated benzylideneacetones, in facile synthesis of difficulty accessible functional pyridines, furans and pyrans is presented here. Biomass-derived chemicals as furfural, gallic, benzoic, cinnamates, and acetone derivatives were used. The structures of all new synthesized compounds were confirmed on the basis of spectral analysis, IR, 1H NMR, 13C NMR, and MS spectroscopy.


Main Subjects

Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 861-867
  • Receive Date: 24 January 2023
  • Revise Date: 09 April 2023
  • Accept Date: 30 April 2023