Unexpected Products of the Reaction of Cyanoacetylhydrazones of Aryl/heteryl Ketones with Hydrazine: A New Route to Aryl/Heteryl Hydrazones, X-ray Structure, and In vitro Anti-proliferative Activity Against NCI 60-cell Line Panel

Document Type : Original Article

Authors

1 Chemistry of Natural & Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Center, Cairo, 12622, Egypt

2 School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

3 Department of Chemistry, Faculty of Science, Helwan University, Cairo, 11795, Egypt.

Abstract

A new unexpected synthetic non-catalytic method for the synthesis of novel heteryl hydrazones for base-modification of nucleoside analogs has been developed. Characterizations of the products have been performed using NMR spectroscopy and single crystal x-ray diffraction analysis. Further in vitro anti-proliferative potency of the compounds against NCI 60 cell lines has been estimated. The results indicate anti-cancer activity by the compounds against several of the cancer cell lines.

Keywords

Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 225-239

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History

  • Receive Date: 04 March 2023
  • Revise Date: 23 April 2023
  • Accept Date: 24 April 2023

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