From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142; Saudi Arabia

2 Laboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire 1092 Tunis, Tunisie, Université de Tunis El Manar

3 İnönü University, Catalysis Research and Application Center, 44280-Malatya, Turkey

4 İnönü University, Faculty of Science and Art, Department of Chemistry, 44280 Malatya, Turkey

5 Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass, 51452, Saudi Arabia

Abstract

The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene) (NHC)] complexes 3. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. The biological activities of the synthesized ligands and their Ru (II) complexes as acetylcholinesterase, antimicrobial, and antioxidant agents were evaluated. The lowest MICs values were obtained with the two complexes 3b and 3d. The enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 3b and 3d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 µg mL-1 respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 µg mL-1 respectively. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibit excellent radical scavenging properties

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History

  • Receive Date: 19 February 2022
  • Revise Date: 01 March 2023
  • Accept Date: 03 April 2023

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