Pyrimidine hydrazide ligand and its metal complexes: synthesis, ‎characterization, and antimicrobial activities

Saeed, S. El-Sayed; Alomari, Budoor A.; Alhakimi, Ahmed N.; Abd El-Hady, M. M.; Alnawmasi, Jawza Sh; Elganzory, Hussein H.; El-Sayed, Wael A.

doi:10.21608/ejchem.2022.173181.7161

Pyrimidine hydrazide ligand and its metal complexes: synthesis, ‎characterization, and antimicrobial activities

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science, Qassim University, Saudi Arabia.

² Department of Chemistry, College of Science, Ibb University, Ibb, Yemen

³ National Research Centre (Scopus affiliation ID: 60014618), Institute of Textile Research and Technology, Dokki, Giza 12622, Egypt.

⁴ Photochemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.

10.21608/ejchem.2022.173181.7161

Abstract

Increasing the resistance to current antimicrobial agents has posed a pressing need for the development ‎of new antimicrobial agents. We, therefore, benefit from the antimicrobial characteristics of pyrimidine ‎derivatives to prepare a new 4-(4-bromophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-‎carbohydrazide ligand. The ligand complexes of (3d; Cr, Mn, Fe, Co, Ni, Cu, and Zn) and 4d -Cd metals ‎are also prepared and characterized by different techniques. The ligand acts as a neutral bidentate and ‎exhibited octahedral geometry. In vitro antibacterial activity of the ligand and its complexes against ‎Staphylococcus aureus and Escherichia coli was investigated. Also, the antifungal against Candida ‎albicans and Aspergillus flavus was evaluated. The results showed that the produced complexes have ‎antibacterial activity higher than the ligand. The Cd(II) complex showed antifungal activity higher than ‎the other complexes.‎

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