Synthesis, Characterization, Antimicrobial/Antitumor Activity of Binary and Ternary Neodymium (III) Complex with 2,2'-((1E,1'E)-(ethane-1,2-diylbis(azaneylylidene)) bis(methaneylylidene)) diphenol and Imidazole

Document Type : Original Article


1 Chemistry Department, Faculty of Science, New Valley University, Alkharga 72511, Egypt

2 Ministry of higher education, Technical Industrial Institutes, Sohag, Egypt


Two new Neodymium(III) complexes with ligand, 2,2'-((1E,1'E)-(ethane-1,2-diylbis(azaneylylidene)) bis(methaneylylidene)) diphenol (H2L) [Nd(H2L)2Cl2]Cl.H2O, and H2L mixed with imidazole (I) [Nd(H2L)2(I)]Cl3.H2O were prepared and characterized with physicochemical methods were used to clarify the structural makeup of the new compounds. [Nd(H2L)Cl2]Cl.H2O and [Nd(H2L)(I)Cl2]H2O were effective antimicrobials, with larger inhibition zones than the reference antibiotic. The antimicrobial efficacy follows the order: gentamicin > [Nd(H2L)(I)Cl2]H2O > [Nd(H2L)Cl2]Cl.H2O > H2L/I > H2L. The cytotoxicity of ligand, binary and ternary complexes against human liver (Hep-G2) and breast (MDA-MB231) carcinoma cell lines was determined by using cisplatin as reference, the complex of [Nd(H2L)(I)Cl2]H2O exhibited the highest activity against two cell lines


Volume 65, Issue 131 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part A)
December 2022
Pages 735-744
  • Receive Date: 07 December 2022
  • Revise Date: 12 December 2022
  • Accept Date: 18 December 2022