Document Type : Review Articles
Authors
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt.
2
Pharmaceutical Chemistry department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo , Egypt Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City , Egypt
4
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.
Abstract
Anthranilic acid scaffold is a pivotal class of amino organic acids used for the construction of many organic candidates exhibiting a wide range of industrial, pharmaceutical, and biological activities. In addition, anthranilic acid derivatives are considered a cheap and efficient stating precursor for the production and synthesis of various marketed available drugs like furosemide (diuretic), tranilast (antiallergic), betrixaban (anticoagulant) and analgesic & anti-inflammatory fenamates. Furthermore, numerous anthranilic acid analogs with potential anticancer, antimicrobial, insecticidal, antiviral, anti-inflammatory activities and other biological activities have been disclosed over the last thirty years. The current review represents a brief and simple summary of different synthetic methodologies and techniques applied for the construction and synthesis of different anthranilic acid analogs and derivatives along with a concise discussion of the potential therapeutic activity of these synthesized derivatives.
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