The synthesis of some new heterocyclic compounds including quinoline moiety. The new 4-chloroacetylaminophenylaminoquinoline derivatives (5a, 5b) were synthesized by condensation of 4,7dichloroquinoline 1 with amines (2a, 2b) following by acylation with 2-chloro acetyl chloride 4. Then, 4-chloroacetylaminophenylaminoquinoline derivatives (5a, 5b) were reacted with different substituted aniline (6a,6b,8a,8b) to afford new 4-acetylaminophenylaminoquinoline derivatives 7(a-c), 9(a-d). The one pot reaction with the synthesized 4-acetylaminophenylaminoquinoline derivative 7c, benzaldehyde 9 and triphenylphosphite 10 in presence of LiClO4 as a Lewis acid catalyst led to the formation of α-aminophosphonate derivative 12 in good yields. The chemical structures of all synthesized compounds were elucidated by the analysis of FT-IR, NMR and MS spectral data. The biological screening data of the newly synthesized compounds were screened for in vitro antimicrobial activity towards gram-positive and gram-negative bacteria strains which possess moderate inhibition zones.
Zain El-Dein, A. M., Abdel Aleem, A. A. H., & El-Sayed, I. E. (2023). Synthesis and Antibacterial Activity of Some Novel Quinoline Analogues. Egyptian Journal of Chemistry, 66(6), 323-330. doi: 10.21608/ejchem.2022.101247.4852
MLA
Aya Moustafa Zain El-Dein; Abdel Aleem Hassan Abdel Aleem; Ibrahim E.T. El-Sayed. "Synthesis and Antibacterial Activity of Some Novel Quinoline Analogues". Egyptian Journal of Chemistry, 66, 6, 2023, 323-330. doi: 10.21608/ejchem.2022.101247.4852
HARVARD
Zain El-Dein, A. M., Abdel Aleem, A. A. H., El-Sayed, I. E. (2023). 'Synthesis and Antibacterial Activity of Some Novel Quinoline Analogues', Egyptian Journal of Chemistry, 66(6), pp. 323-330. doi: 10.21608/ejchem.2022.101247.4852
VANCOUVER
Zain El-Dein, A. M., Abdel Aleem, A. A. H., El-Sayed, I. E. Synthesis and Antibacterial Activity of Some Novel Quinoline Analogues. Egyptian Journal of Chemistry, 2023; 66(6): 323-330. doi: 10.21608/ejchem.2022.101247.4852
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