N-Acetylcysteine (NAC) is an antioxidant compound with antitumor properties. In this study NAC was encapsulated into niosomes for treatment tumor in mice. NAC- encapsulated niosomes’ morphology and Fourier-transform infrared spectroscopy (FTIR) analysis were measured. Fifteen mice male BALB/c were divided to three groups: group1: negative control, group2 positive control (tumor group), group3 treated with NAC- encapsulated niosomes after tumor growth. The effect of NAC- encapsulated niosomes on the tumor was determined by measuring tumor size progress, comet assay, oxidative stress parameters (GSH, Nitric Oxide, histopathological investigation. Transmission electron microscopy examination found that NAC- encapsulated niosomes have spherical shape. Tissues histological studies emphasized the protective effect of NAC- encapsulated niosomes against tumor. In conclusion oral delivery of NAC- encapsulated niosomes improved antitumor effect.
Ali, A. A., El-Gebaly, R., & Mohamad, E. (2023). N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles.. Egyptian Journal of Chemistry, 66(5), 379-384. doi: 10.21608/ejchem.2022.155918.6745
MLA
Abeer A. Ali; Reem El-Gebaly; Ebtesam A. Mohamad. "N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles.". Egyptian Journal of Chemistry, 66, 5, 2023, 379-384. doi: 10.21608/ejchem.2022.155918.6745
HARVARD
Ali, A. A., El-Gebaly, R., Mohamad, E. (2023). 'N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles.', Egyptian Journal of Chemistry, 66(5), pp. 379-384. doi: 10.21608/ejchem.2022.155918.6745
VANCOUVER
Ali, A. A., El-Gebaly, R., Mohamad, E. N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles.. Egyptian Journal of Chemistry, 2023; 66(5): 379-384. doi: 10.21608/ejchem.2022.155918.6745
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