Traditional, One pot Three Component Synthesis and Anti-Bacterial Evaluations of Some New Pyrazoline Derivatives

Document Type : Original Article


1 Department of Chemistry, College of Science, University of Sulaimani, Kurdistan Region, Iraq

2 Department of Chemistry, University of Sulaimani, College of science, Iraq -Kurdistan Region

3 Department of Chemistry, College of Education, Salahaddin University-Hawler, Erbil-Kurdistan, Iraq


In this work synthesized a new series of pyrazoline compounds containing azo linkages via classical and one pot three component reactions. The progress started with 3-chloro,4-methyl aniline which has been diazotized and coupled with 4-hydroxy acetophenone to form azo compound 1-(3-((3-chloro-4-methylphenyl) diazenyl)-4-hydroxyphenyl) ethan-1-one (1) and converted to 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl) diazenyl) phenyl) ethan-1-one (2). The later azo compound subjected to both classical and one pot method to give target pyrazoline derivatives. The structure of all new obtained compounds were supported by spectral data (1H-NMR, 13CNMR, Dept.135, and FT-IR). Finally, some pyrazoline derivatives were estimated for their anti-bacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive. The results showed significant activity against both types of bacteria.


Main Subjects

Volume 65, Issue 10
October 2022
Pages 239-248
  • Receive Date: 27 March 2022
  • Revise Date: 27 June 2022
  • Accept Date: 14 August 2022
  • First Publish Date: 14 August 2022