Newly Created Hybrid Nanomaterial for Treatment of Lung Carcinoma

Shaaban, Aya; Salem, Ahmad; Elramly, Faten; Ahmed, Ekrami; Moawed, Fatma; Hegazy, Marwa Galal Eldeen

doi:10.21608/ejchem.2022.134874.6127

Newly Created Hybrid Nanomaterial for Treatment of Lung Carcinoma

Document Type : Original Article

Authors

¹ Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt

² Faculty of science and humanities Prince Sattem Bin Abd Alaziz University, Hawtit Ban Tamim; Saudia Arabia

³ Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

⁴ Biochemistry, faculty of Science, Ain Shams university

10.21608/ejchem.2022.134874.6127

Abstract

Deficient passage of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Interest has been manifested in use of chitosan-based nanoparticles with utilizing metal oxide hybrid nanocomposite in nanomedicine. We synthesis, characterize, and investigate a hybrid nanomaterial (CHNM) anti-cancer activity. A developed CHNM of magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer were characterized by FTIR, X-ray diffraction, TEM and SEM. Anti-cancer effects were evaluated in A549 cell line. CHNM nanoparticles showed a diameter of ∼240 nm with a negatively charged surface (−25.4 ± 3.75 mV) and mean particle size of 24.2 ± 7.89 nm. CHNM showed a high encapsulation efficiency (78%), drug loading efficiency (80%) and maximum cisplatin release (2- 6 h). CHNM showed improved anti-cancer activity on A549 cells (IC50=50.8 µg/ml). In conclusion, magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer could be used as promising lung cancer treatment system.

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