Document Type : Original Article
Authors
1
Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
2
Professor of Organic chemistry, Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
3
Biochemistry-Medical Biochemistry Department, National Research Centre, Cairo, Egypt
4
Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.
5
Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
This study determines the effect of insulin administration on fasting blood glucose (FBG), lipid profile "serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol), insulin and insulin resistance in women with Type 2 Diabetes (T2DM). T2DM is a multifactorial disease promoted by genetic and environmental factors, and there is a tight association between T2DM and dyslipidemia. Inulin is prebiotic that has been shown to improve insulin concentrations and ameliorate the lipid profile in people with diabetes. 100 T2DM females with predetermined criteria took four grams of inulin-type prebiotic daily for three weeks, with their FBG, Insulin, Insulin resistance (IR), and lipid profile measured before and after. This clinical study demonstrated that the inulin supplementation significantly decreased FBG, serum TG, TC, LDL, insulin, and IR levels and significantly increased HDL compared to the measurements before supplementation. This means that inulin may play a role in correcting the metabolic disorders caused by high fructose diets by improving carbohydrate and lipid metabolism.
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