Metabolic Pathway of Resistant Starch via Micro Biome in Healthy and Hyperglycemic Rats

Document Type : Original Article


1 Food science department, Faculty of Agriculture, Cairo Giza 12613, Egypt

2 National institute for nutrition

3 Food science department, National Nutrition Institute, Cairo, Egypt and Food science department, Faculty of Agriculture, Cairo Giza 12613, Egypt

4 Food Science Department, Faculty of Agriculture, Cairo University, Giza 12613, Egypt


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Green banana powder (GBP) was given to diabetic and healthy rats in two different concentrations to see how it affected them. The goal of the planned study was to see how GBP feeding affected diabetic rats. Method: Sixty male albino rats were separated into six groups: the control group was fed a standard diet, while the GV and G VI groups were given 5 and 2.5 percent of a GBP diet, respectively, to assess their safety. To induce diabetes, GII was given an intraperitoneal "IP" injection of streptozotocin (STZ) (40 mg/kg BW). For 30 days, GIII and G IV diabetic rats were given 5 and 2.5 % of the GBP diet, respectively. Rats were exposed to biological evaluation measures throughout the investigation (feed intake, growth curve). Biochemical assays (serum diabetes markers, liver functions; GSH and MDA as antioxidants indication in liver tissue) and histopathological characteristics of the liver and pancreas were performed at the end of the treatment period. Finally, the results showed that the GBP had no physiological deleterious effects in healthy rats throughout the research except for around 20% of the rats, who showed some histopathological alterations after consuming a 5% GBP. From biological and biochemical parameters, treatment with 2.5 % GBP alleviated STZ-induced diabetes more than treatment with 5 % GBP. Conclusion: GBP contains high-resistance starch, which promotes a healthy gut microbiome, and bioactive composites that have a beneficial impact on diabetes via antioxidants and anti-inflammatory effects when consumed in safe doses to avoid negative impacts. Recommendation: Consuming little amounts of green banana for short times may be more useful and safer in terms of diabetes management.


Main Subjects

Volume 65, Issue 10
October 2022
Pages 1-16
  • Receive Date: 03 May 2022
  • Revise Date: 05 June 2022
  • Accept Date: 12 June 2022
  • First Publish Date: 12 June 2022