Investigation of COVID-19 By Theoretical Docking of Medicines With Two Proteins

Document Type : Original Article

Authors

1 Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq

2 Northern Technical University, IRAQ

3 Department of Biochemistry, College of Medicine, University of Mosul, IRAQ

4 Ministry of Health, IRAQ

Abstract

This study examined the docking of two inhibition for SARS-Cov-2 virus (or COVID-19) these proteins are (6wtt and 6xa4) with nine pharmaceutical compounds (Aminoglutethimide, 4-Aminosalicylic acid, Felbamate, Hydroflumethiazide, Modafinil, Nepafenac, Oxcarbazepine, and Trichlormethiazide) which are used in the general human's life. These pharmaceuticals having different active groups in the structure conformation like (-NH2) and (-OH). Docking was applied the investigate the interaction between these medicines with the proteins using Molecular Operating Environment software (MOE).

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Egyptian Journal of Chemistry
Volume 65, Issue 131 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part A)
December 2022
Pages 247-253

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History

  • Receive Date: 20 January 2022
  • Revise Date: 15 April 2022
  • Accept Date: 27 April 2022

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