Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats

Document Type : Original Article


1 Holding Company for Water and Waastewater - Gharbia Branch, Tanta

2 Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

3 Zoology Department, Faculty Of Science, Al-Azhar University, Cairo, Egypt


Recently, in particular, environmental contaminants have continued to be the most potential cause of many diseases, those of toxic metals which are capable of accumulating within vital organs of both humans and animals, inducing reactive oxygen species (ROS) production and causing severe health hazards within biological systems. Nickel (Ni) and chromium (Cr) are toxic elements producing highly reactive radicals which are able to disable enzymatic antioxidants through binding to their active sites. The present study has been designed to evaluate the protective role of curcumin against testicular dysfunction induced by nickel-chromium combination. The concentrations of Ni and Cr as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the testicular tissue while hematological biomarkers were being measured in the blood of experimental rats. Mixture metals resulted in significant variances within testicular tissues. However, oral administration of curcumin provided a significantly protective role against combined toxicity of nickel-chromium and reduced histopathological alterations due to antioxidant property represented in scavenging and chelating properties as concluded from the present investigations.


Main Subjects

Volume 65, Issue 131 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part A)
December 2022
Pages 279-289
  • Receive Date: 23 January 2022
  • Revise Date: 10 March 2022
  • Accept Date: 12 April 2022