Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.

Taha, Rania H.; El-Fakharany, Esmail; El-Shafiey, Zienab; Salman, Aida; Mansour, Mai; Yahia, Mohamed

doi:10.21608/ejchem.2022.117920.5313

Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.

² Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt.

³ Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, 11795 Cairo, Egypt.

10.21608/ejchem.2022.117920.5313

Abstract

The present investigation relates to the new method of preparing schiff base of 4-(2-Hydroxy-1,2-diphenyl-ethylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one as well as the preparation of metallic compounds with certain ions such as (La(III), Gd(III), Co(II), and Cd (II)) in normal and nano-size and their biological applications of their ability to treat colon and breast cancer cells without affecting normal cells. These synthesized compounds have been characterized using different analytical techniques including physicochemical studies such as elemental analysis, electrical conductivity, Uv-visible, IR, nuclear magnetic resonance (NMR), mass spectrometry, magnetic and thermal studies as well as imagining using transmission electron microscopy (TEM). In vitro, the anti-cancer activity of these synthesized compounds was investigated, and their mechanism of action was detected. The results proved that these compounds have the anti-cancer activity against colon cancer (Caco-2) and breast cancer (MCF-7) cell lines at very low concentrations up to 8.27 mg/ml. It was found that the Cd (II) compound showed the highest selectivity against cancer cells without affecting the normal (Vero) cells with selective index (SI) values about 62 times for breast cancer cells and about 51 times for colon cancer cells.

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