Comparative study of Some biochemical and Immunological parameters of patients with COVID-19 disease and non-infected people

Qaddoori, Hayder T; Hassan, Abdullah; Al-shoky, Mohammed Sachit; K. Kalil, Yaser; Mudhafar, Mustafa

doi:10.21608/ejchem.2022.113854.5172

Comparative study of Some biochemical and Immunological parameters of patients with COVID-19 disease and non-infected people

Document Type : Original Article

Authors

¹ Institute technical baquba, Middle technical university, dayala

² chemistry department, college science, diyaia university

³ Al-kut university college, medical laboratory techniques

⁴ College Alqalam University, Karkuk, Iraq

⁵ Department of Anesthesia and Intensive Care Techniques, Faculty of AL, Tuff Collage, Karbala, 56001, Iraq

10.21608/ejchem.2022.113854.5172

Abstract

Abstract:
The objective of the present study was to evaluate eight biochemical and Immunological parameters and comparison their level in the infected and non-infected people. The methodology include two parts biochemical assays included aspartate transaminase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea breath test (UREA), and creatinine, and Immunological parameters included D-dimer, ferritin, interleukin 6 (IL-6), C-Reactive Protein (CRP). The result detected by Cobas e411, Cobas C111 device. Results obtained showed high levels of all parameters of covid-19 patients in comparing with the control group patients, with significant differences (p < 0.05). Receiver operating characteristic (ROC) curve showed a high area under the curve for all parameters Area under the ROC Curve (AUC) for all parameters were 1.000, except Patent Cooperation Treaty (PCT) was 0.796) and show high sensitivity for all parameters (sensitivity for all parameters were 100%, except PCT was 75%). The present study was observed significant correlations among the studied of the parameters.

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