Organosilicon Surfactants as Antitumor Agents

Document Type : Original Article

Authors

Petrochemicals Department, Egyptian Petroleum Research Institute, Cairo, 11727, Egypt.

Abstract

Organosilicon surfactants draw scientific attention due to their significant biological action as they offer the real possibility to improve their pharmacological properties because of easier penetration through lipophilic barriers inside the body. Synthesis, structure and spectroscopic characterization of cobalt (II), copper (II) and zinc (II) coordination compounds with N-dodecyl-N-trimethyl silane ammonium iodide are presented in this research. N-dodecyl-N-trimethyl silane ammonium iodide and its complexes with cobalt, copper and zinc chlorides were characterized structurally using Ultraviolet-Visible and Fourier Transform Infra-red spectra. Surface parameters of the prepared surfactants were investigated including, critical micelle concentration, maximum surface excess, minimum surface area, effectiveness, and efficiency. Free energy of micellization and adsorption were also calculated. The cytotoxic activity of various metallomicelle surfactants was tested against five lines of human tumor cells [ HEPG2 (liver), MCF-7 (breast), HCT-116 (colon), HEP2 (larynx), and HFB4 (normal)]. The results showed that zinc (II) and cobalt (II) complexes have substantial surface and cytotoxic activity whereas copper (II) complex showed less surface and cytotoxic activity.

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Egyptian Journal of Chemistry
Volume 65, Issue 10
October 2022
Pages 577-584

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History

  • Receive Date: 07 January 2022
  • Revise Date: 11 February 2022
  • Accept Date: 23 February 2022

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