Preparation and diagnosis of Zn(II), Cd(II) and Hg(II) complexes with Schiff base ligand derived from trimethoprim

Ahmed, Fadiaa J.; AbdAlqader, Baraa; Haddad, Raoah A.; Abed, Rana Ramzi; Saleh, Mohanad Yakdhan

doi:10.21608/ejchem.2022.119210.5362

Preparation and diagnosis of Zn(II), Cd(II) and Hg(II) complexes with Schiff base ligand derived from trimethoprim

Document Type : Original Article

Authors

¹ University of Mosul / College of Education of Pure science / Department of Chemistry

² Mosul university

³ Department of Chemistry, College of Education for pure science, University of Mosul

10.21608/ejchem.2022.119210.5362

Abstract

Synthesis and identification of some new zinc(II), cadmium(II), and Mercury(II) complexes their ligand 3 were done. The resulting compounds were identified using various physicochemical techniques such as electrical conductivity, magnetic susceptibility, infrared spectroscopy, electronic (ultraviolet) spectra, 1H-NMR spectroscopy, atomic absorption, and CHN elemental analysis. Through magnetic measurements and ultraviolet and infrared electronic spectra, we found that the shape of the resulting complexes is tetrahedral around zinc(II), cadmium(II), and Mercury(II), while the molar electrical conductivity results of the complexes prepared in neutral medium confirmed that they are electrolytes in a solvent. DMF and DMSO in a ratio (1:1). The prepared complexes in the basic medium were non-electrolyte. Zn(II), Cd(II), and Hg(II), complexes showed tetrahedral geometry with general formula [M(L3)](NO3)2 and [M(L3)] in neutral and basic medium respectively. Then the antibacterial activity of the prepared ligand and complexes against bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella spp). Neither the complexes nor ligand compounds showed antibacterial activity.

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