Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

Document Type : Original Article

Authors

1 Northern Technical University

2 Al-noor University College

3 Dept. of Medical Laboratories Technique Al-Noor University College, Mosul

4 Department of Chemistry, College of Education for pure science, University of Mosul

Abstract

Synthesis of mixed metal complexes were done through reaction of two drugs such as antipyrine, or ciprofloxacin with Metronidazole to have eight complexes. Physical, chemical and antibacterial activity of new complexes were studied. These mixed ligands were further coordinating with bivalent transition metals in a metal: ligands mixture ratio 1:1. These complexes were characterized by using elemental analysis and physical properties, in addition molar conductance in DMF which showed non-electrolytic behavior. FT-IR spectra revealed absorption bands for new ligands and metal complexes that agreed with the propose structures and the electronic spectra verified that these complexes display six-coordinate octahedral geometry. Antibacterial activity showed good results.

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  • Receive Date: 23 January 2022
  • Revise Date: 05 February 2022
  • Accept Date: 08 February 2022
  • First Publish Date: 08 February 2022