Synthesis and characterization of novel isoxazolidine-thiosemicarbazone hybrid derivatives as precursor of unnatural amino acids

Document Type : Original Article


1 Department of Chemistry, College of Science, Qassim University, buraidah

2 University of Monastir

3 Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.

4 university of monastir


Novel sixteen enantiopure isoxazolidine-(thio)semicarbazone hybrid derivatives were synthesized by condensation of isoxazolidines based on benzaldehyde derivatives with (thio)semicarbazide in good yield. The analysis of the 1D NMR and NOESY spectra of all compounds unambiguously confirms the E-stereochemistry of the synthesized (thio)semicarbazones.


Main Subjects

  • Receive Date: 19 December 2021
  • Revise Date: 15 January 2022
  • Accept Date: 01 February 2022
  • First Publish Date: 01 February 2022