One- Pot Synthesis of New Pyranopyrazoles Via Domino Multicomponent Reaction

Document Type : Original Article

Authors

1 Dept. of Chemistry, College of Science, Mosul University.

2 Deprt. of chemistry- College of Science-University of mosu

Abstract

An active heterocyclic unite building represented by 1,3,4-Thiadiazole-2,5-dithiole (1) was prepared through the reaction of carbon disulfide and hydrazine hydrate .This unite building was reacted with hydrazine hydrate to afford the corresponding 2,5-dihydrazino -1,3,4-thiadiazole(2)which then undergoes one-pot catalyst-free multicomponent reaction with malononitrile, substituted aldehyde and ethyl acetoacetate to obtained 2,5-di(3-methyl-4-aryl-pyrano[2,3-c]pyrazole-5-amino-6-cyno-1-yl)-1,3,4-thiadiazole (3-9). All prepared compounds were elucidated by available methods represented by M.P,T.L.C,FT-IR and for some compounds 1H.NMR.

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  • Receive Date: 08 January 2022
  • Revise Date: 26 January 2022
  • Accept Date: 28 January 2022
  • First Publish Date: 28 January 2022