Cobalt (II), Nickel (II) and Copper (II) complexes of Tetradentate Schiff bases ligands derived from 4-Nitro-O-phenylenediamine: Synthesis, Characterization, cyclic voltammetry and biological studies

Document Type : Original Article

Authors

1 Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon;

2 Department of Chemistry, Faculty of Science, University of Buea, Cameroon;

3 Department of Chemistry, Faculty of Science, University of Douala, Cameroon;

4 Department of Chemistry, Faculty of Science, University of Dschang, Cameroon.

Abstract

Two tetradentate Schiff base ligands, (N,N’-bis((2-hydroxy-1-phenyl)methylidene)- 4-nitrophenyl-1,2-diamine (H2L1) and N,N’-bis((2-hydroxy-1-naphthyl)methylidene)-4-nitrophenyl-1,2-diamine (H2L2)) have been synthesized by the condensation of 4-nitro-orthophenylenediamine with 2-hydroxy-1-naphthaldehyde and salicylaldehyde respectively in absolute ethanol and reacted with Co(II), Ni(II) and Cu(II) salts to form the corresponding complexes. The compounds were characterized by UV-vis., FT-IR, 1H NMR, 13C NMR, ESI-mass spectra, elemental analysis, and molar conductance measurements. The ligands were found to be tetradentate, coordinating to the metal ions through the azomethine nitrogen and oxygen atoms of phenol and naphthol and the sulphur atoms of thiophenol groups. Conductance measurements shows that these compounds are molecular. Cyclic voltammetry studies shows that the Co(III)/Co(II) and Ni(III)/Ni(II) redox systems are quasi-reversible involving a mono electronic transfer while Cu(III)/Cu(II) is irreversible. In vitro antimicrobial screening against five bacterial strains (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and five fungal strains (Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida parapsilosis), shows that some of the compounds exhibited moderate antibacterial and antifungal activities compared to the reference drugs. Antioxidant studies reveal that the complexes are more potent than the ligands to eliminate free radicals.
Keywords: Tetradentate Schiff base ligands, 4-nitro-orthophenylenediamine, 2-hydroxy-1-naphthaldehyde, metal complexes, cyclic voltammetry, antimicrobial activity.

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  • Receive Date: 30 June 2021
  • Revise Date: 31 December 2021
  • Accept Date: 27 January 2022
  • First Publish Date: 27 January 2022