Effect of Carob, Doum, and Cinnamon Powder on Blood Lipid Profile in Diabetic Rats

Hussein, Wafaa Ahmed; Salem, Amany Abd-Elfattah; Fahmy, Hany Aziz; Mouneir, Samar Mohamed; Soliman, Amira Sh.; Abbas, Mohamed Said

doi:10.21608/ejchem.2022.114446.5202

Effect of Carob, Doum, and Cinnamon Powder on Blood Lipid Profile in Diabetic Rats

Document Type : Original Article

Authors

¹ Special Food and Nutrition Department, Food Technology Research Institute, Agricultural Research Center, Giza, Egypt

² Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University , Giza, Egypt

³ Faculty of African Postgraduate Studies, Cairo University

⁴ Faculty of African Postgraduate Studies, Cairo University, P.O. 12613 Cairo, Egypt

10.21608/ejchem.2022.114446.5202

Abstract

Abstract
Researchers in this study tested the effects of carob, doum, and cinnamon powder on diabetic rats' blood lipid profiles. During the experiment, 36 adult albino male rats were employed. After the rats had a chance to adjust to their new surroundings, they were divided into six groups at random. Group 1 was used as a negative control and was fed a simple diet for the length of the research. STZ (streptozotocin) (40 mg/kg BW) was administered to the rats in groups of two to six. As soon as the diabetic rats in Group 2 became diabetic, their use as a positive control was ceased. Glibenclamide (10mg/kg BW/day orally) was given to the group that was fed a normal diet. Group (3) got no therapy (as standard drug). Group (4) utilized carob powder, Group (5) used doum powder, and Group (6) used cinnamon powder (6). After the trial, the results show that the plants have grown. Serum LDL-c (Low-density lipoprotein–cholesterol) and TC (total cholesterol) and TG (Triglyceride) levels decreased, but HDL-C (Hight density lipoprotein–cholesterol) ratios increased considerably throughout the feeding phase of the study. Carob, doum, and cinnamon powder meals reduced the levels of blood aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT) enzymes in rats compared to the positive control diets. All the examined diets had the same result. Additionally, diabetic rats had better renal function than diabetic rats under positive control. Histopathological differences were seen in the pancreas of diabetic rats compared to animals given carob, doum, and cinnamon powder. We advise that three plant powders (carob, doum, and cinnamon) be employed as a novel possible treatment for diabetic, obese, and atherosclerotic individuals.

Keywords

Main Subjects