Snake Venoms-Based Compounds as Potential Anticancer Prodrug: Sand Viper Cerastes Cerastes as a Model

Document Type : Review Articles

Authors

1 Zoology department, faculty of Science, Port Said university, Port Said, Egypt.

2 Professor of Molecular Toxicology & Physiology of zoology, Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

3 Zoology department, Faculty of Science, Port Said university, Port Said, Egypt

4 Genetics Unit, Histology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Abstract

Cancer is a major public health problem, recently known as the disease of the millennium. Proliferation of tumor cells, angiogenesis and the relationship between cancer cells and extracellular matrix components are important events in carcinogenesis. Many of these pathways are being used as targets for new anticancer therapeutic approaches. Various venoms and their toxins have shown possible anticancer effects on human cancer cell lines, providing new perspectives for drug development. For instance, snake venoms is a complex mixture of different proteins, peptides, enzymes, carbohydrates and other bioactive molecules that are either secreted by the snake in predation or protection against threats. Snake venoms are largely cytotoxic to the malignant cells compared to the normal one. Therefore; venoms, have a number of therapeutic actions which make them an attractive approach for cancer therapy. In this review, we shed light onto the importance of the venom isolated from a desert-horned or Egyptian sand viper Cerastes cerastes as a potential therapeutic drug

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History

  • Receive Date: 04 October 2021
  • Revise Date: 11 January 2022
  • Accept Date: 19 January 2022

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