A Review of Chalcones: Synthesis, Reactions, and Biological Importance

Mukhtar, Shorouk S.; Morsy, Nesrin M.; Hassan, Ashraf S.; Hafez, Taghrid S.; Hassaneen, Hamdi M.; Saleh, Fatma M.

doi:10.21608/ejchem.2022.112735.5125

A Review of Chalcones: Synthesis, Reactions, and Biological Importance

Document Type : Review Articles

Authors

¹ Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki 12622, Egypt

² Organometallic and Organometalloid Chemistry Department,National Research Centre

³ Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

⁴ Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622 Cairo, Egypt

⁵ Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

10.21608/ejchem.2022.112735.5125

Abstract

Chalcones are considered an important scaffold in organic compounds. Many of their derivatives have a lot of applications. Therefore, this review was covered some synthesis methods of chalcones such as Claisen-Schmidt’s condensation, coupling reaction, continuous-flow deuteration reaction, and other reactions. Also, some reactions were discussed such as the synthesis of seven, six, and five-membered ring heterocyclic compounds. Moreover, some of their biological applications were mentioned like antimicrobial, anticancer, anti-inflammatory, antioxidants, and others with some details.

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