A Review of Chalcones: Synthesis, Reactions, and Biological Importance

Document Type : Review Articles

Authors

1 Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki 12622, Egypt

2 Organometallic and Organometalloid Chemistry Department,National Research Centre

3 Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

4 Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622 Cairo, Egypt

5 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Abstract

Chalcones are considered an important scaffold in organic compounds. Many of their derivatives have a lot of applications. Therefore, this review was covered some synthesis methods of chalcones such as Claisen-Schmidt’s condensation, coupling reaction, continuous-flow deuteration reaction, and other reactions. Also, some reactions were discussed such as the synthesis of seven, six, and five-membered ring heterocyclic compounds. Moreover, some of their biological applications were mentioned like antimicrobial, anticancer, anti-inflammatory, antioxidants, and others with some details.

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Volume 65, Issue 8 - Serial Number 8
August 2022
Pages 379-395
  • Receive Date: 24 December 2021
  • Revise Date: 06 January 2022
  • Accept Date: 13 January 2022
  • First Publish Date: 15 January 2022