Synthesis, Cytotoxic, and Apoptotic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar Hydrazone Derivatives

El-Sayed, Wael A.; Elganzory, Hussein H.; Khalaf-Allaha, Abeer S. A.; Mohamed, Ashraf M.; Abd-Rabou, Ahmed A.; Abdel-Monem, Yasser Kamal

doi:10.21608/ejchem.2021.106807.4902

Synthesis, Cytotoxic, and Apoptotic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar Hydrazone Derivatives

Document Type : Review Articles

Authors

¹ Photochemistry Department, National Research Centre, Dokki, Giza 12622 Egypt

² Department of Chemistry, College of Science, Qassim University, Buraidah, 51452 Saudi Arabia

³ Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom ,Egypt.

⁴ Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622 Egypt,

⁵ Hormones Department, Medicine and Clinical Studies Research Institute, & Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Giza, Egypt.

10.21608/ejchem.2021.106807.4902

Abstract

Hydrazones have pronounced properties that allow them promising for a range of synthetic applications. In the current study, new acid hydrazide compounds incorporating substituted arylglyl and succinyl moieties were prepared via multistep process including formation of the corresponding acid compounds followed by formation of the derived esters and hydrazinloysis reactions. The synthesized acylhydraizdes were used for the preparation of novel functionalized sugar hydrazones and their derived per-O-acetylated derivatives. The hydrazones and their acetylated analogs were studied for their cytotoxic activity against hepatic HCT116 and HepG2 and MCF7 breast cancer cell lines and it was revealed that hydrazones 16, 17 and 18 possessing per-O-acetylated sugar moieties showed high cytotoxic activity compared to the reference drug.

Keywords